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Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid hemorrhage in rats

《医学前沿（英文）》 2021年 第15卷 第6期   页码 887-902 doi: 10.1007/s11684-021-0879-9

摘要： Monocarboxylic acid transporter 1 (MCT1) maintains axonal function by transferring lactic acid from oligodendrocytes to axons. Subarachnoid hemorrhage (SAH) induces white matter injury, but the involvement of MCT1 is unclear. In this study, the SAH model of adult male Sprague-Dawley rats was used to explore the role of MCT1 in white matter injury after SAH. At 48 h after SAH, oligodendrocyte MCT1 was significantly reduced, and the exogenous overexpression of MCT1 significantly improved white matter integrity and long-term cognitive function. Motor training after SAH significantly increased the number of ITPR2+SOX10+ oligodendrocytes and upregulated the level of MCT1, which was positively correlated with the behavioral ability of rats. In addition, miR-29b and miR-124 levels were significantly increased in SAH rats compared with non-SAH rats. Further intervention experiments showed that miR-29b and miR-124 could negatively regulate the level of MCT1. This study confirmed that the loss of MCT1 may be one of the mechanisms of white matter damage after SAH and may be caused by the negative regulation of miR-29b and miR-124. MCT1 may be involved in the neurological improvement of rehabilitation training after SAH.

关键词： microRNAs     monocarboxylate transporter 1     motor training     subarachnoid hemorrhage     white matter injury    

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Essential training steps to achieving competency in the basic intraoperative transesophageal echocardiography

null

《医学前沿（英文）》 2015年 第9卷 第1期   页码 123-128 doi: 10.1007/s11684-014-0366-7

摘要：

Guidelines for the intraoperative transesophageal echocardiography (TEE) examination have defined a detailed standard for medical professionals, particularly anesthesiologists, on how a TEE exam should proceed. Over the years, TEE has gained substantial popularity and emerged as a preferred monitoring modality to aid in perioperative management and decision making during hemodynamic instability situations or critical care settings. TEE training pathways and practice guidelines have been well established in western countries and many regions of the world. However, TEE training and practice information for anesthesiologists are lacking in China. As innovative technologies develop, other educational models have emerged to aid in obtaining competency in basic TEE exam. Hence, establishing a consensus on the ideal TEE training approach for anesthesiologists in China is urgently needed. Developing an effective curriculum that can be incorporated into an anesthesiology resident’s overall training is also necessary to provide knowledge and skills toward competency in basic TEE exam. With evolving medical system reforms and increasing demands for intraoperative hemodynamic monitoring to accommodate surgical innovations, anesthesiology professionals are increasingly obliged to perform intraoperative TEE exams in their current and future practices. To overcome obstacles and achieve significant progress in using the TEE modality to help in intraoperative management and surgical decision making, publishing basic TEE training guidelines for China’s anesthesiologists is an important endeavor.

关键词： transesophageal echocardiography     guidelines     training     competency    

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perioperative transesophageal echocardiography: should new guidelines exist for limited echocardiography training

null

《医学前沿（英文）》 2012年 第6卷 第3期   页码 332-337 doi: 10.1007/s11684-012-0212-8

摘要：

Bedside limited echocardiography, or focused cardiac ultrasound, continues to gain popularity in many emergency rooms, intensive care units, and operating rooms as a rapid method of assessing unstable patients. Effective monitoring of cardiovascular function in conditions like cardiac arrest or near-arrest is the crucial step to guide successful resuscitative efforts. Transesophageal echocardiography (TEE) has emerged as one of the preferred cardiac diagnostic and monitoring modalities in the intraoperative setting due to the fact that it is less invasive than many other monitors, is immediately accessible, and allows for continuous real-time monitoring of cardiac function. However, the minimum training requirements needed for the anesthesia provider to obtain the competency, knowledge, and skills for basic certification in perioperative TEE far exceed those developed for other medical specialties. We believe there is an urgent need to develop (1) practical guidelines for emergent perioperative TEE use for anesthesiologists and (2) a requisite educational curriculum to teach the basic skills necessary to aid in the diagnosis and treatment of cardiac arrest or near-arrest scenarios. The measures elucidated in this report summarize the efforts of the Department of Anesthesiology at the University of Florida in establishing the necessary steps to make this process not only practical, but accessible to all trainees. We hope that these collective efforts will provide more trainees the confidence in utilizing TEE to aid in establishing a diagnosis in critical situations.

关键词： transesophageal echocardiography     curriculum     competency training     hemodynamic instability    

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Role of exercise training on insulin resistance and TNF-α in high-fat diet rats

Hui SUN MD, Xiuling DENG MM, Fangxi XIAO MD, Lulu CHEN MD, Huiqing LI MD,

《医学前沿（英文）》 2009年 第3卷 第4期   页码 403-407 doi: 10.1007/s11684-009-0071-0

摘要： This study investigated the effect of exercise training on insulin resistance and serum and adipose TNF-α in high-fat diet-induced insulin-resistant rats. Thirty male Wistar rats were randomly divided into two groups: normal control group (NC; =8) that accepted normal chow and high-fat diet group (HF; =22) that fed on high-fat diet to induce insulin resistance model. The HF group was randomly assigned to two subgroups after 18 weeks: sedentary group (SE; =10) and exercise training group (ET; =12) that performed swimming exercise training for 6 weeks, while both groups continued high-fat diet. Changes of body weight, lipid profile, and fasting plasma glucose and insulin were measured. The insulin sensitivity index (ISI) was calculated. Serum concentration of TNF-α was detected by ELISA. The expression of TNF-α mRNA and protein in adipose tissue was examined by using real-time fluorescence quantitative polymerase chain reaction (PCR) and Western blot, respectively. After 18 weeks, compared with the NC group, body weight, blood lipid, glucose, and insulin in the HF group were significantly elevated, while the ISI decreased obviously, which suggested that insulin resistance appeared in the HF group. After exercise training for 6 weeks, compared with the SE group, both ISI and serum TNF-α concentration in the ET group were decreased significantly; however, the expression levels of TNF-α mRNA and protein in adipose tissue increased by 27.5% and 20.5%, respectively. In conclusion, exercise training ameliorates insulin resistance. The reduction of the level of serum TNF-α and the increased expression of TNF-α in adipose tissue by exercise training may be involved in this mechanism.

关键词： exercise training     insulin resistance     tumor necrosis factor-α    

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Linear ultrasonic motor using quadrate plate transducer

Jiamei JIN, Chunsheng ZHAO

《机械工程前沿（英文）》 2009年 第4卷 第1期   页码 88-91 doi: 10.1007/s11465-009-0016-y

摘要： A linear ultrasonic motor using a quadrate plate transducer was developed for precision positioning. This motor consists of two pairs of Pb(Zr,Ti)O piezoelectric ceramic elements, which are piezoelectrically excited into the second-bending mode of the motor stator’s neutral surface in two orthogonal directions, on which the tops of four projections move along an elliptical trajectory, which in turn drives a contacted slider into linear motion via frictional forces. The coincident frequency of the stator is easily obtained for its coincident characteristic dimension in two orthogonal directions. The performance characteristics achieved by the motor are: 1) a maximum linear speed of more than 60 mm/s; 2) a stroke of more than150 mm; 3) a driving force of more than 5.0 N; and 4) a response time of about 2 ms.

关键词： ultrasonic motor     quadrate plate     coincident frequency     alternant contact    

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Design and analysis of linear oscillating motor for linear pump application-magnetic field, dynamics

Zongxia JIAO,Tianyi WANG,Liang YAN

《机械工程前沿（英文）》 2016年 第11卷 第4期   页码 351-362 doi: 10.1007/s11465-016-0407-9

摘要：

A linear oscillating motor is an electromagnetic actuator that can achieve short-stroke reciprocating movement directly without auxiliary transmission mechanisms. It has been widely used in linear pump applications as the source of power and motion. However, because of the demand of high power density in a linear actuation system, the performance of linear oscillating motors has been the focus of studies and deserves further research for high power density. In this paper, a general framework of linear oscillating motor design and optimization is addressed in detail, including the electromagnetic, dynamics, and thermal aspects. First, the electromagnetic and dynamics characteristics are modeled to reveal the principle for optimization. Then, optimization and analysis on magnetic structure, resonant system, and thermal features are conducted, which provide the foundation for prototype development. Finally, experimental results are provided for validation. As a whole, this process offers complete guidance for high power density linear oscillating motors in linear pump applications.

关键词： linear oscillating motor     linear pump     magnetic field     motor optimization    

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modified neural learning algorithm for online rotor resistance estimation in vector controlled induction motor

A. CHITRA,S. HIMAVATHI

《能源前沿（英文）》 2015年 第9卷 第1期   页码 22-30 doi: 10.1007/s11708-014-0339-1

摘要： Online estimation of rotor resistance is essential for high performance vector controlled drives. In this paper, a novel modified neural algorithm has been identified for the online estimation of rotor resistance. Neural based estimators are now receiving active consideration as they have a number of advantages over conventional techniques. The training algorithm of the neural network determines its learning speed, stability, weight convergence, accuracy of estimation, speed of tracking and ease of implementation. In this paper, the neural estimator has been studied with conventional and proposed learning algorithms. The sensitivity of the rotor resistance change has been tested for a wide range of variation from -50% to+50% on the stability of the drive system with and without estimator. It is quiet appealing to settle with optimal estimation time and error for the viable realization. The study is conducted extensively for estimation and tracking. The proposed learning algorithm is found to exhibit good estimation and tracking capabilities. Besides, it reduces computational complexity and, hence, more feasible for practical digital implementation.

关键词： neural networks     back propagation (BP)     rotor resistance estimators     vector control     induction motor    

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Review of human–robot coordination control for rehabilitation based on motor function evaluation

《机械工程前沿（英文）》 2022年 第17卷 第2期 doi: 10.1007/s11465-022-0684-4

摘要： As a wearable and intelligent system, a lower limb exoskeleton rehabilitation robot can provide auxiliary rehabilitation training for patients with lower limb walking impairment/loss and address the existing problem of insufficient medical resources. One of the main elements of such a human–robot coupling system is a control system to ensure human–robot coordination. This review aims to summarise the development of human–robot coordination control and the associated research achievements and provide insight into the research challenges in promoting innovative design in such control systems. The patients’ functional disorders and clinical rehabilitation needs regarding lower limbs are analysed in detail, forming the basis for the human–robot coordination of lower limb rehabilitation robots. Then, human–robot coordination is discussed in terms of three aspects: modelling, perception and control. Based on the reviewed research, the demand for robotic rehabilitation, modelling for human–robot coupling systems with new structures and assessment methods with different etiologies based on multi-mode sensors are discussed in detail, suggesting development directions of human–robot coordination and providing a reference for relevant research.

关键词： human–robot coupling     lower limb rehabilitation     exoskeleton robot     motor assessment     dynamical model     perception    

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我国全科医生培养现状与发展策略

刘颖,蒋国平,任菁菁

《中国工程科学》 2019年 第21卷 第2期   页码 74-78 doi: 10.15302/J-SSCAE-2019.02.005

摘要：

经过近30年的不断探索和实践，我国全科医生队伍建设取得了一定的进展，初步建立了以“5+3”为主、“3+2”为辅的全科医生培养模式，但我国仍面临严重缺乏合格全科医生的情况。本文通过对我国全科医生培养现状的研究，了解到当前我国全科医生岗位缺乏吸引力，全科医生培养制度和体系不够完善，缺乏完善的过程考核机制，住培基地准入和再认证机制不完善，持续职业发展教育亟待规范。通过对国际上主要国家发展全科医生经验的回顾研究，建议我国应当切实提升全科医生待遇；以“岗位胜任力”为导向，建立完善的全科医生培训过程考核体系；统一全科医生住培基地准入条件，建立常态化基地评估认证机制；设置全科持续职业发展教育基地。

关键词： 全科医生     人才培养     岗位胜任力    

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Estimation of composite load model with aggregate induction motor dynamic load for an isolated hybrid

Nitin Kumar SAXENA,Ashwani Kumar SHARMA

《能源前沿（英文）》 2015年 第9卷 第4期   页码 472-485 doi: 10.1007/s11708-015-0373-7

摘要： It is well recognized that the voltage stability of a power system is affected by the load model and hence, to effectively analyze the reactive power compensation of an isolated hybrid wind-diesel based power system, the loads need to be considered along with the generators in a transient analysis. This paper gives a detailed mathematical modeling to compute the reactive power response with small voltage perturbation for composite load. The composite load is a combination of the static and dynamic load model. To develop this composite load model, the exponential load is used as a static load model and induction motors (IMs) are used as a dynamic load model. To analyze the dynamics of IM load, the fifth, third and first order model of IM are formulated and compared using differential equations solver in Matlab coding. Since the decentralized areas have many small consumers which may consist large numbers of IMs of small rating, it is not realistic to model either a single large rating unit or all small rating IMs together that are placed in the system. In place of using a single large rating IM, a group of motors are considered and then the aggregate model of IM is developed using the law of energy conservation. This aggregate model is used as a dynamic load model. For different simulation studies, especially in the area of voltage stability with reactive power compensation of an isolated hybrid power system, the transfer function of the composite load is required. The transfer function of the composite load is derived in this paper by successive derivation for the exponential model of static load and for the fifth and third order IM dynamic load model using state space model.

关键词： isolated hybrid power system (IHPS)     composite load model     static load     dynamic load     induction motor load model     aggregate load    

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The next step of community health construction: Training general practitioners and implementing health

Kan ZHANG MM, Wei DONG MM, Ying-Yao CHEN MD,

《医学前沿（英文）》 2010年 第4卷 第2期   页码 134-138 doi: 10.1007/s11684-010-0041-6

摘要： This article discusses the concept of health management and stresses that community health management should be the starting point of community health service, necessitating a paradigm shift from observing the treatment-oriented medical model to observing the prevention-and-health management-based medical model. Community health construction has entered a new phase, one which highlights the need to train general practitioners in practice-based life cycle health management. In addition, general practitioners should assume the mission of implementing community health management.

关键词： community health     general practitioners     health management    

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maize-based food-feed-energy systems to limited phosphate resources—a new Sino-German international research training

null

《农业科学与工程前沿（英文）》 2019年 第6卷 第4期   页码 443-444 doi: 10.15302/J-FASE-2019288

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maize-based food-feed-energy systems to limited phosphate resources—a new Sino-German international research training

null

《农业科学与工程前沿（英文）》 2019年 第6卷 第4期   页码 313-320 doi: 10.15302/J-FASE-2019282

摘要：

Phosphate is supplied to agriculture by mining and fertilizer production, followed by different steps of phosphate utilization, including primary production, feed and food consumption, and conversion of biomass, with accumulation in soils, but little recycling and severe environmental losses. Phosphate is a limited essential nutrient, however, with very uneven distribution worldwide. Closing the cycle and reducing primary phosphate consumption are fundamental future challenges. Maize has a relatively high phosphate requirement. China and Germany together cover the whole range of maize production systems. The new Sino-German international research training group “Adaptation of Chinese and German maize-based food-feed-energy systems to limited phosphate resources” (AMAIZE-P) was initiated in 2018 as a joint venture of the China Agricultural University (Beijing, China) and the University of Hohenheim (Stuttgart, Germany). The interdisciplinary and complementary research is driven by the hypothesis that under phosphate limited conditions, high productivity and high phosphate use efficiency can be achieved simultaneously by adapting phosphate cycling and availability (sources) to the multipurpose phosphate demands (sinks) in maize-based food-feed-energy systems. The educational program for doctoral researchers in China and Germany includes joint block seminars, thematic field trips, case studies, methodological courses, doctoral researchers’ conferences, intercultural training sessions and personal training.

关键词： international research training group     limited resources     maize     phosphate    

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面向21世纪的超声电机技术

赵淳生

《中国工程科学》 2002年 第4卷 第2期   页码 86-91

摘要：

叙述了新型微特电机——超声电机的特点，回顾了20世纪末期超声电机的发展和应用情况，介绍了南京航空航天大学超声电机研究中心在超声电机研究方面的进展，预测了21世纪国内外市场对超声电机技术的需求，列举了超声电机技术在我国国防和国民经济各部门的应用前景，指出了超声电机技术的发展趋势，针对我国超声电机技术开发和研究的现状，提出了为发展我国超声电机技术亟需解决的若干关键问题。

关键词： 超声电机     压电陶瓷     摩擦材料    

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Research on the control systems of a precision linear motor drive device

YAN Han, WANG Xian-kui, DUAN Guang-hong

《机械工程前沿（英文）》 2006年 第1卷 第3期   页码 260-264 doi: 10.1007/s11465-006-0036-9

摘要： The model of a precision linear motor drive device (PLMDD) and its control requirements are analyzed. In order to enhance the tracking and anti-disturbance performance of the system, its third-order model is established, and disturbance-observer based input revising feedforward error compensation robust control algorithm, combined with integral-separated proportional integral derivative (PID) control algorithm is proposed. This includes feedback control algorithm and feedforward control algorithm. The feedback controller improves system tracking performance and suppresses load and mechanical disturbance while the feedforward controller compensates phase hysteresis introduced by feedback control. Theoretical analyses, simulations and experiments show that this control method increases the tracking precision of PLMDD from ±5 μm to ±2 μm and dramatically improves its anti-disturbance ability.

关键词： feedforward     tracking     ±5     anti-disturbance performance     algorithm    

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标题 作者 时间 类型 操作

Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid hemorrhage in rats

期刊论文

Essential training steps to achieving competency in the basic intraoperative transesophageal echocardiography

null

期刊论文

perioperative transesophageal echocardiography: should new guidelines exist for limited echocardiography training

null

期刊论文

Role of exercise training on insulin resistance and TNF-α in high-fat diet rats

Hui SUN MD, Xiuling DENG MM, Fangxi XIAO MD, Lulu CHEN MD, Huiqing LI MD,

期刊论文

Linear ultrasonic motor using quadrate plate transducer

Jiamei JIN, Chunsheng ZHAO

期刊论文

Design and analysis of linear oscillating motor for linear pump application-magnetic field, dynamics

Zongxia JIAO,Tianyi WANG,Liang YAN

期刊论文

modified neural learning algorithm for online rotor resistance estimation in vector controlled induction motor

A. CHITRA,S. HIMAVATHI

期刊论文

Review of human–robot coordination control for rehabilitation based on motor function evaluation

期刊论文

我国全科医生培养现状与发展策略

刘颖,蒋国平,任菁菁

期刊论文

Estimation of composite load model with aggregate induction motor dynamic load for an isolated hybrid

Nitin Kumar SAXENA,Ashwani Kumar SHARMA

期刊论文

The next step of community health construction: Training general practitioners and implementing health

Kan ZHANG MM, Wei DONG MM, Ying-Yao CHEN MD,

期刊论文

maize-based food-feed-energy systems to limited phosphate resources—a new Sino-German international research training

null

期刊论文

maize-based food-feed-energy systems to limited phosphate resources—a new Sino-German international research training

null

期刊论文

面向21世纪的超声电机技术

赵淳生

期刊论文

Research on the control systems of a precision linear motor drive device

YAN Han, WANG Xian-kui, DUAN Guang-hong

期刊论文